The best F-15 flight simulation is Lock On: Modern Air Combat. This flight sim allows you to fly eight different fighter jets, including the F-15.
Another flight sim where you can fly the F-15 is X-Plane 10. This flight simulator has better graphics than Lock On, but it doesn’t allow you to fire missiles or engage enemy aircraft for the full fighter pilot experience. You will have to install the following add-on to use the F-15 in X-Plane.